Coenzyme Q10 for Migraine

There has been a lot of buzz about Coenzyme Q10 as an effective treatment for a variety of illnesses, including Parkinson’s and heart disease. Recent studies have also found it to be a very effective treatment in the prevention of migraine. It can be taken orally in tablet or capsule form, or in a migraine supplement like Axon Relief. If you’re still wondering what Coenzyme Q10 is, we’ve provided a handy little guide. Read on.

What is Coenzyme Q10?

Coenzyme Q10, or CoQ10, is an antioxidant that is naturally produced in the body. It works at the cellular level to aid in cell maintenance and growth. CoQ10 is found in certain foods like whole grains, fatty fish (trout, herring, etc.), spinach, organ meats (heart, liver, etc.), beef, and chicken, but the amounts are usually not adequate for raising its levels within the body. Couple this with the fact that as the body ages, CoQ10 decreases and it is easy to see how some people may need a CoQ10 supplement.


A randomized control trial of CoQ10 focused specifically on using it for migraine (Sandor et al). There were 43 migraine patients who participated. The trial itself was placebo controlled, randomized, and double blind, classified as fair per CHS standards and Class II per AAN and AHS standards. While there were some differences in the treatments that many of the patients were receiving, the impact on the trial results were considered to be very minimal.

The placebo was administered to all subjects during the first month to establish a baseline. In the second month some patients were given 100 mg of CoQ10 and the other patients were given a placebo. This treatment was administered over a three month period. In month four the group that was taking the CoQ10 experienced a significant decrease in the frequency of their migraine attacks compared to the baseline. The effects of the supplement began in the first month of taking it, but steadily increased in effectiveness until it reached a maximum effectiveness in month three.

How to take Coenzyme Q10 for migraine

Coenzyme Q10 is usually taken in capsule form by mouth or is included in supplement drinks or mixes like Axon Relief Migraine Prevention. The CHS guidelines strongly recommend CoQ10 for migraine and advise a daily dose of 300 mg, given 150 mg po TID, or 150 mg by mouth twice daily. Guidelines for AAN/AHS and the Federation of Neurological Sciences (EFNS) give a Level C recommendation for CoQ10 as a preventative treatment for migraine.

Every glass of Axon Relief has 300 mg of CoEnzyme Q10, along with other migraine busting ingredients. Mix it with water for a delicious dose of some of migraine prevention while boosting your fluid intake and avoiding dehydration. Try it for yourself and you could have more migraine free days.

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